Prenatal acetaminophen exposure in meconium and the risk of ADHD- Role of Confounding by Indication

Motherisk Int J 2020;1;24   Gideon Koren MD FRCPC FACMT Professor and Head of Pharmacology, Adelson School of Medicine, Ariel University, Israel E mail: gidiup_2000@yahoo.com Tel 972587194777 Jacob V. Aranda MD, PhD, FRCPC, FAAP Professor of Pediatrics and Ophthalmology and Director of Neonatology State University of New York Downstate Health Sciences University   Question: In…

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Salivary Melatonin Levels in Pregnant Women with Insomnia: A Prospective Controlled Study

Motherisk Int J 2020;1;23   Kamelia Mirdamadi1,2, Gideon Koren,3,4 University of Toronto, Department of Pharmaceutical Sciences, Toronto, ON, Ca Hospital for Sick Children, Division of Clinical Pharmacology and Toxicology, Toronto, ON Ariel University, Department of Clinical Pharmacology, Israel Motherisk Israel Program Corresponding Author: Kamelia Mirdamadi Leslie Dan Faculty of Pharmacy, Department of Pharmaceutical Sciences 144…

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Women using antiepileptic drugs: How much folic acid per day is sufficient?

Motherisk Int J 2020;1;22   Yusuf Cem Kaplan MD (1), Gideon Koren MD (2, 3) Independent Researcher, Berlin, Germany (1), Adelson Faculty of Medicine, Ariel University (2) and Motherisk Israel Program (3)   Question: I have a patient who has been receiving lamotrigine for her focal onset seizures. She is considering pregnancy and asked me…

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Covid-19 re-infection in pregnancy?

Motherisk Int J 2020;1;21   Gideon Koren MD FRCPC FACMT, Vered Nachmias Friedler MD MBA, Renato Fusman MD, Susy Mann RN Leumit Health Services and Adelson School of Medicine, Ariel University, Israel   Question This week I have seen several media reports of Covid-19 proven- re infections. Because pregnancy appears to be a risk factor…

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Bonjesta- the first dual release combination of doxylamine-pyridoxine for morning sickness

Motherisk Intl J 2020;1;19 Bonjesta- the first dual release combination of doxylamine-pyridoxine for morning sickness Gideon Koren, Rana Cohen, Adelson School of Medicine, Ariel University and Motherisk Israel Program   Question: The delayed release of doxylamine/ pyridoxine (Diclegis®) works well in many of my patients with morning sickness. The problem I have is that it…

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Fetal alcohol spectrum disorder in twin pregnancies

Motherisk Int J 2020;1:18   Gideon Koren MD, FRCPC, FACMT and Rana Cohen BSc Pharm, MBA Adelson School of Medicine, Ariel University and Motherisk Israel Program   Question: If a heavily drinking mother has twins, are both affected by FASD? Answer: Not necessarily. Studies in humans and experiments in laboratory animals reveal full concordance in…

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Motherisk Rounds: Neural Tube Defects and Dydrogesterone

Motherisk Int J 2020;1:17   Gideon Koren MD FRCPC FACMT Ariel University and Motherisk Israel, Shamir Medical Center   Question: We have a case of cervical insufficiency resulting in two miscarriages of otherwise normal fetuses. In the subsequent two pregnancies the woman received dydrogesterone (DYD). In both cases the fetuses were diagnosed with encephalocele and…

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The Risks of Codeine to Breastfed Infants- Facts and Fallacies

Motherisk Int J 2020;1:16   David Chitayat MD, FRCPC, FACCG (1) and Gideon Koren MD, FRCPC, FACMT (2) The Prenatal Diagnosis and Medical  Genetics Program, Department of Obstetrics and Gynecology, Mount Sinai Hospital, The University of Toronto, ON, Canada (1); Motherisk International Program and Ariel University, Ariel, Israel (2)     Question: It has been…

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